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In a multi-nation study made public Monday, the drug flibanserin appeared to increase desire and sexual satisfaction in women by several measures by modulating serotonin and other neurotransmitters.

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Unlike Viagra, which is used to treat male erectile dysfunction by increasing blood flow to the genitals, this drug acts on the woman's brain to enhance mood. Lead researchers from University of Ottawa -- underwritten by Boehringer Ingelheim Pharmaceuticals -- say the drug is effective in treating a newly coined condition known as hypoactive sexual desire disorder HSDD or lack of libido. The drug acts on the central nervous system, keeping serotonin, norepinephrine and dopamine "in balance," she told ABCNews.

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The Phase III placebo-controlled studies on flibanserin also raise questions about whether HSDD is a legitimate medical condition or another pharmaceutical company invention to sell drugs. HSDD was classified as a disorder by the American Psychiatric Association in and is characterized by low desire, accompanied by "anxiety, guilt and relationships issues," according to Jolly. Reinisch said while the study was "interesting," there were more questions about the data -- women surveyed were 18 to 50, a wide range, and from different countries. Premenopausal women treated for 24 weeks showed ificant improvements in sexual desire and functioning compared with those on a placebo.

The 1, study participants were required to be in a "stable, communicative, monogamous, heterosexual" relationship for at least one year. All exhibited generalized acquired sexual dysfunction disorder or "little or no receptivity" to sexual activity.

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Those who had secondary problems with arousal or orgasm were excluded from the study, as well as those with psychiatric and depressive disorders or those who had taken medication that might diminish or enhance sexual function within four weeks prior to entering the study.

About 43 percent of women experience sexual problems, according to another Boehringer Ingelheim study that examined their prevalence in a representative sample of 30, U. But only 12 percent found those problems "distressing," according to Dr. As for those who were bothered by their lack of desire, "this group of women deserves effective treatment.

Many safe and effective options are available for treating women's sexual problems, typically addressing the underlying cause, which can be fatigue, stress, relationship conflict, depression or antidepressant medication.

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Because flibanserin is an acting agent and not a hormone, like testosterone, Shifren, said she would want to see the safety data regarding mood effects and possibly blood pressure before prescribing the drug. Beyond this study, the drug must show clinical improvement for women, effectively decreasing her level of distress about her sexuality, "for it to be effective," she said.

Problems with sexual desire are "a big deal," for women, according to Dr. Women have many reasons for lack of libido: stress, caregiving roles and lack of self-esteem -- " a big one," said Savard, and it's difficult to "label" women with a simple diagnosis like HSSD.

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Still, because flibanserin works on the brain, "which is women's biggest sex organ," it might make sense that women would benefit from the drug. Savard said she had "no doubt" the study increased episodes of sexual desire, but women must also side effects, especially because this drug is aimed at younger women. It's better that women understand what her individual cause is, like self esteem, which is the biggest. Flibanserin has shown positive effects with a strong safety profile, according to Dr.

Guay, director for the Center for Sexual Function at the Lahey Clinic in Bostonwho served as a medical consultant on the trials. The drug works in the brain to modulate serotonin, which is a negative transmitter for sexual function.

He admits the drug may do little to help women become orgasmic, who, like men, can be affected by obesity and drugs like beta blockers that decrease the flow of blood to the genitals. LOG IN. We'll notify you here with news about.

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